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Papillary Carcinomas of the Gallbladder: Analysis of Noninvasive and Invasive Types

2005; American Medical Association; Volume: 129; Issue: 7 Linguagem: Inglês

10.1043/1543-2165(2005)129[905

1543-2165

Jorge Albores‐Saavedra, Matthew Tuck, Bernadette K. McLaren, Kelley Carrick, Donald E. Henson,

Cancer Diagnosis and Treatment

Abstract Context.—Although papillary carcinomas have been recognized as distinct morphologic variants of gallbladder neoplasms, they have been lumped together in a single group despite the recognition of noninvasive and invasive types. As a result, the biologic behavior of each type remains undescribed. Objective.—To compare the biologic behavior of noninvasive and invasive papillary carcinomas of the gallbladder. Design.—The clinical and morphologic features of 16 noninvasive papillary carcinomas (>1 cm) of the gallbladder were analyzed, and their clinical behavior was compared with that of 370 invasive papillary carcinomas recorded in the Survey Epidemiology and End Results (SEER) Program of the National Cancer Institute from 1973 through 2001. The biologic behavior of invasive papillary carcinomas was compared with that of invasive nonpapillary carcinomas of the gallbladder recorded in SEER. Hematoxylin-eosin–stained sections were available for review in the 16 noninvasive papillary carcinomas. The num...