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Neoclerodane Diterpenes as a Novel Scaffold for μ Opioid Receptor Ligands

2005; American Chemical Society; Volume: 48; Issue: 15 Linguagem: Inglês

10.1021/jm048963m

1520-4804

Wayne W. Harding, Kevin Tidgewell, Nathan Byrd, Howard Cobb, Christina M. Dersch, Eduardo R. Butelman, Richard B. Rothman, Thomas E. Prisinzano,

Receptor Mechanisms and Signaling

Structural modification of salvinorin A, the active component of Salvia divinorum, has resulted in the synthesis of novel neoclerodane diterpenes with opioid receptor affinity and activity. We report in this study a nonnitrogenous neoclerodane diterpene with mu opioid receptor affinity (13) that is an agonist at mu opioid receptors. This represents the identification of a novel structural class of mu opioid receptor agonists.