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Stat1-dependent and -independent pathways in IFN-γ-dependent signaling

2002; Elsevier BV; Volume: 23; Issue: 2 Linguagem: Inglês

10.1016/s1471-4906(01)02118-4

1471-4981

Chilakamarti V. Ramana, M. Pilar Gil, Robert D. Schreiber, George R. Stark,

Pharmacological Effects of Natural Compounds

The paradigm that emerged from studies during the past decade established a central role for Jak-Stat (signal transducer and activator of transcription) signaling pathways in promoting the diverse cellular responses induced by interferon gamma (IFN-gamma). However, recent studies have shown that the IFN-gamma receptor activates additional signaling pathways and can regulate gene expression by Stat1-independent pathways. The diversity of gene-expression patterns mediated by Stat1-dependent and -independent mechanisms and the balance between these two pathways play an important role in the biological response to IFN-gamma.