Produção Nacional
Revisado por pares
Condensação de Knoevenagel de aldeídos aromáticos com o ácido de Meldrum em água: uma aula experimental de Química Orgânica Verde
2012; Brazilian Chemical Society; Volume: 35; Issue: 3 Linguagem: Inglês
10.1590/s0100-40422012000300036
ISSN1678-7064
AutoresSílvio Cunha, Lourenço Luís Botelho de Santana,
Tópico(s)Various Chemistry Research Topics
ResumoGREEN ORGANIC CHEMISTRY.This work describes an undergraduate experiment for the synthesis of Knoevenagel adduct of Meldrum's acid with nine aromatic aldehydes, using water as the solvent, in an adaptation of a previously reported synthetic protocol.The synthesis was straightforward, requiring a period of two hours, and is suitable for undergraduate experimental courses on green chemistry.In addition, quantitative analyses of the relative reactivity of p-nitrobenzaldehyde and p-metoxi-benzaldehyde was evaluated through the competitive reaction of equimolar amounts of these aldehydes with one equivalent of Meldrum's acid, using gas chromatography to quantify the composition of the reaction mixture.
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