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Spherical Bioactive Glass with Enhanced Rates of Hydroxyapatite Deposition and Hemostatic Activity

2006; Wiley; Volume: 2; Issue: 11 Linguagem: Inglês

10.1002/smll.200600177

1613-6829

Todd A. Ostomel, Qihui Shi, Chia‐Kuang Tsung, Hongjun Liang, Galen D. Stucky,

Facial Trauma and Fracture Management

SmallVolume 2, Issue 11 p. 1261-1265 Communication Spherical Bioactive Glass with Enhanced Rates of Hydroxyapatite Deposition and Hemostatic Activity† Todd A. Ostomel Dr., Todd A. Ostomel Dr. Department of Chemistry and Biochemistry University of California, Santa Barbara, CA 93106, USA, Fax: (+1) 805-893-4120Search for more papers by this authorQihui Shi, Qihui Shi Department of Chemistry and Biochemistry University of California, Santa Barbara, CA 93106, USA, Fax: (+1) 805-893-4120Search for more papers by this authorChia-Kuang Tsung, Chia-Kuang Tsung Department of Chemistry and Biochemistry University of California, Santa Barbara, CA 93106, USA, Fax: (+1) 805-893-4120Search for more papers by this authorHongjun Liang Dr., Hongjun Liang Dr. Department of Chemistry and Biochemistry University of California, Santa Barbara, CA 93106, USA, Fax: (+1) 805-893-4120Search for more papers by this authorGalen D. Stucky Prof., Galen D. Stucky Prof. stucky@chem.ucsb.edu Department of Chemistry and Biochemistry University of California, Santa Barbara, CA 93106, USA, Fax: (+1) 805-893-4120Search for more papers by this author Todd A. Ostomel Dr., Todd A. Ostomel Dr. Department of Chemistry and Biochemistry University of California, Santa Barbara, CA 93106, USA, Fax: (+1) 805-893-4120Search for more papers by this authorQihui Shi, Qihui Shi Department of Chemistry and Biochemistry University of California, Santa Barbara, CA 93106, USA, Fax: (+1) 805-893-4120Search for more papers by this authorChia-Kuang Tsung, Chia-Kuang Tsung Department of Chemistry and Biochemistry University of California, Santa Barbara, CA 93106, USA, Fax: (+1) 805-893-4120Search for more papers by this authorHongjun Liang Dr., Hongjun Liang Dr. Department of Chemistry and Biochemistry University of California, Santa Barbara, CA 93106, USA, Fax: (+1) 805-893-4120Search for more papers by this authorGalen D. Stucky Prof., Galen D. Stucky Prof. stucky@chem.ucsb.edu Department of Chemistry and Biochemistry University of California, Santa Barbara, CA 93106, USA, Fax: (+1) 805-893-4120Search for more papers by this author First published: 02 October 2006 https://doi.org/10.1002/smll.200600177Citations: 179 † This work was funded by the Office of Naval Research, ONR Awards N00014-04-1-0654 and N00014-06-1-0145, and made use of the MRL central facilities supported by the MRSEC Program of the National Science Foundation under Award No. DMR05-20415. TAO and QS contributed equally to this work. Supporting Information Available: Synthesis of mesoporous bioactive glass microspheres and cements, materials characterization including SEM, TEM, BET, and XRD. Thromboelastograph clotting parameters. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract High-surface-area mesoporous bioactive glass materials have been developed, which demonstrate accelerated deposition rates of hydroxyapatite when immersed in simulated body fluids. Also, a novel blood-clotting application for bioactive glass materials, composed of microspheres (see TEM image), has been designed. Both bone growth and blood clotting are surface dependent hence the effect of changing the shape of the glass particles on the in vitro deposition rate and hemostatic efficacy has been investigated. Citing Literature Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2296/2006/z600177_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume2, Issue11Special Issue: Special Section - Assembly at the Nanoscale - Toward Functional Nanostructured MaterialsNovember 2006Pages 1261-1265 RelatedInformation