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Sustained melatonin treatment blocks body mass, pelage, reproductive, and fever responses to short day lengths in female Siberian hamsters

2011; Wiley; Volume: 51; Issue: 2 Linguagem: Inglês

10.1111/j.1600-079x.2011.00874.x

1600-079X

Ashley M. Fenn, Laura K. Fonken, Randy J. Nelson,

Adipose Tissue and Metabolism

Journal of Pineal ResearchVolume 51, Issue 2 p. 180-186 Sustained melatonin treatment blocks body mass, pelage, reproductive, and fever responses to short day lengths in female Siberian hamsters Ashley M. Fenn, Ashley M. Fenn Authors contributed equally to this work.Search for more papers by this authorLaura K. Fonken, Laura K. Fonken Authors contributed equally to this work.Search for more papers by this authorRandy J. Nelson, Randy J. Nelson Department of Neuroscience and Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH, USASearch for more papers by this author Ashley M. Fenn, Ashley M. Fenn Authors contributed equally to this work.Search for more papers by this authorLaura K. Fonken, Laura K. Fonken Authors contributed equally to this work.Search for more papers by this authorRandy J. Nelson, Randy J. Nelson Department of Neuroscience and Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH, USASearch for more papers by this author First published: 02 March 2011 https://doi.org/10.1111/j.1600-079X.2011.00874.xCitations: 7 Address reprint requests to Ashley M. Fenn, 460 Medical Center Drive, Room no 246, Columbus, OH 43210, USA.E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Abstract: Winter imposes physiological challenges on individuals including increased thermoregulatory demands, risk of infection, and decreased food availability. To survive these challenges, animals living outside the tropics must appropriately distribute their energetic costs across the year, including reproduction and immune function. Individuals of many species use the annual cycle of changing day lengths (photoperiod), which is encoded by the nightly duration of melatonin secretion, to adjust physiology. Siberian hamsters exposed to short days (SD) (long nights/prolonged endogenous melatonin secretion) enhance some aspects of immune function, but curtail other energetically expensive immune functions including the febrile response. The purpose of this study was twofold. First, we determined whether sustained melatonin treatment would inhibit the development of the SD phenotype in female hamsters as it does in males. Second, we examined whether the SD attenuation of fever would be blocked by continuous exposure to exogenous melatonin. Hamsters were implanted with melatonin or empty capsules, housed in either long days (LD) or SD for 8–9 weeks, and then challenged with lipopolysaccharide; body temperature and locomotor activity were recorded. Unlike hamsters with empty capsules, hamsters with melatonin implants did not respond to SD and maintained a LD phenotype including summer-like spleen, uterine and body masses, and pelage characteristics. Further, sustained melatonin treatment blocked the SD attenuation of febrile responses and prolonged the behavioral components of the sickness response. 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Ann NY Acad Sci 1998; 856: 33. Citing Literature Volume51, Issue2September 2011Pages 180-186 ReferencesRelatedInformation