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Persistent tactile allodynia and spinal glia activation in the K/BxN serum transfer arthritis model

2010; BMJ; Volume: 69; Issue: Suppl 2 Linguagem: Inglês

10.1136/ard.2010.129643l

1468-2060

Christina A. Christianson, Maripat Corr, Gary S. Firestein, Tony L. Yaksh, Camilla I. Svensson,

Osteoarthritis Treatment and Mechanisms

Chronic pain is a major health problem affecting approximately 20% of the population resulting in marked reduced quality of life for the individual, as well as extensive costs for society. A large-scale survey undertaken in 15 European countries showed that 40% of the people who reported persistent pain (>6 months) had joint pain and that osteoarthritis (OA) and rheumatoid arthritis (RA) combined was the most common cause of pain (42%). 1 Preclinical studies of pain mechanisms in RA have …