Produção Nacional
Revisado por pares
Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorum
2004; Instituto Oswaldo Cruz, Ministério da Saúde; Volume: 99; Issue: 3 Linguagem: Inglês
10.1590/s0074-02762004000300015
ISSN1678-8060
AutoresIzabel Cristina Piloto Ferreira, Maria Valdrinez Campana Lonardoni, Gérzia M. C. Machado, Leonor L. Leon, Lucílio Gobbi Filho, Luís Henrique Bissoli Pinto, Arildo José Braz de Oliveira,
Tópico(s)Insect Pest Control Strategies
ResumoInfections due to protozoa of the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries. The drugs of choice for the treatment of leishmaniasis are the pentavalent antimonials (SbV), which present renal and cardiac toxicity. Besides, the precise chemical structure and mechanism of action of these drugs are unknown up to date. In order to find new drugs against leishmaniasis, we have been studying extracts of Brazilian trees. In the present study, we have evaluated the effectiveness of an alkaloid extract of Aspidosperma ramiflorum Muell. Arg. (Apocynaceae), against the extracellular forms promastigotes of L. (L.) amazonensis and L. (V.) braziliensis. The alkaloid extract of A. ramiflorum was much more effective against L. (L.) amazonensis (LD50 < 47 µg/ml) than L. (V.) braziliensis. Based on these in vitro results against L. (L.) amazonensis new studies should be made to find the compounds with anti-leishmanial activity.
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