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Somatic Mutation in Anti‐Phosphorylcholine Antibodies

1987; Wiley; Volume: 96; Issue: 1 Linguagem: Inglês

10.1111/j.1600-065x.1987.tb00509.x

1600-065X

Ursula Malipiero, Nina S. Levy, Patricia J. Gearhart,

Protein purification and stability

Immunological ReviewsVolume 96, Issue 1 p. 59-74 Somatic Mutation in Anti-Phosphorylcholine Antibodies Ursula V. Malipiero, Ursula V. Malipiero Department of Biochemistry, The John Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, U.S.ASearch for more papers by this authorNina S. Levy, Nina S. Levy Department of Biochemistry, The John Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, U.S.ASearch for more papers by this authorPatricia J. Gearhart, Patricia J. Gearhart Department of Biochemistry, The John Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, U.S.ASearch for more papers by this author Ursula V. Malipiero, Ursula V. Malipiero Department of Biochemistry, The John Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, U.S.ASearch for more papers by this authorNina S. Levy, Nina S. Levy Department of Biochemistry, The John Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, U.S.ASearch for more papers by this authorPatricia J. Gearhart, Patricia J. Gearhart Department of Biochemistry, The John Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, U.S.ASearch for more papers by this author First published: April 1987 https://doi.org/10.1111/j.1600-065X.1987.tb00509.xCitations: 60AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES Baumal, R., Birshtein, B. K., Coffino, P. & Scharff, M. D. (1973) Mutations in immunoglobulin-producing mouse myeloma cells. Science 182, 164. 10.1126/science.182.4108.164 CASPubMedWeb of Science®Google Scholar Blomberg, B., Traunecker, A., Eisen, H. & Tonegawa, S. (1981) Organization of four mouse γ light chain immunoglobulin genes. Proc Natl. Acad. Sei. USA 78, 3765. 10.1073/pnas.78.6.3765 CASPubMedWeb of Science®Google Scholar Bothwell, A. L. M., Paskind, M., Reth, M., Imanishi-Kari, T, Rajewsky, K. & Baltimore, D. (1981) Heavy chain variable region contribution to the NPb family of antibodies: Somatic mutation evident in a γ2a variable region. Cell 24, 625. 10.1016/0092-8674(81)90089-1 CASPubMedWeb of Science®Google Scholar Brenner, S. & Milstein, C. (1966) Origin of antibody variation. Nature 111, 242. 10.1038/211242a0 Web of Science®Google Scholar Brodeur, P. H. & Riblet, R. (1984) The immunoglobulin heavy chain variable region (Igh-V) locus in the mouse. I. One hundred Igh-V genes comprise seven families of homologous genes. Eur. J. Immunol. 14, 922. 10.1002/eji.1830141012 CASPubMedWeb of Science®Google Scholar Capra, J. D., Berek, C. & Eichman, K. (1976) Structural studies on induced antibodies with defined idiotypic specificities. III. N-terminal amino acid sequence of the heavy and light chains of mouse anti-streptococcal antibodies - A5A, S8, and S117. J. Immunol. 111, 7. Google Scholar Capra, J. D., Slaughter, C, Milner, E. C. B., Estess, R & Tucker, P W. (1982) The cross-reactive idiotype of A-strain mice. Serological and structural studies. Immunology Today 3, 332. 10.1016/0167-5699(82)90018-4 CASPubMedWeb of Science®Google Scholar Clarke, S. H., Huppi, K., Ruezinsky, D, Staudt, L., Gerhard, W. & Weigert, M. (1985) Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin. J. Exp. Med. 161, 687. 10.1084/jem.161.4.687 CASPubMedWeb of Science®Google Scholar Cory, S., Tyler, B. M. & Adams, J. M. (1981) Sets of immunoglobulin VK genes homologous to ten cloned VK sequences: implications for the number of germline VK genes. J. Mol. Appl. Genet. 1, 103. CASPubMedGoogle Scholar Crews, S., Griffin, J., Huang, H., Calame, K. & Hood, L. (1981) A single VH gene segment encodes the immune response to phosphorylcholine: Somatic mutation is correlated with the class of the antibody. Cell 25, 59. 10.1016/0092-8674(81)90231-2 CASPubMedWeb of Science®Google Scholar Darsley, M. J. & Rees, A. R. (1985) Nucleotide sequences of five antilysozyme monoclonal antibodies. EMBO J. 4, 393. 10.1002/j.1460-2075.1985.tb03641.x CASPubMedWeb of Science®Google Scholar D'Hoostelaere, L. A. & Gibson, D. M. (1986) The organization of immunoglobulin variable kappa chain genes on mouse chromosome 6 Immunogenetics 23, 260. 10.1007/BF00373021 CASPubMedWeb of Science®Google Scholar Diamond, B. & Scharff, M. D. (1984) Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity. Proc. Acad. Sci. USA 81, 5841. 10.1073/pnas.81.18.5841 CASPubMedWeb of Science®Google Scholar Drake, J. W. (1970) The molecular basis of mutation. Holden-Day, San Francisco . Google Scholar Gearhart, P. J. (1982) Generation of immunoglobulin variable gene diversity. Immunology Today 3, 107. 10.1016/S0167-5699(82)80026-1 CASPubMedWeb of Science®Google Scholar Gearhart, P. J. & Bogenhagen, D. F. (1983) Clusters of point mutations are found exclusively around rearranged antibody variable genes. Proc. Natl. Acad. Sci. USA 80, 3439. 10.1073/pnas.80.11.3439 CASPubMedWeb of Science®Google Scholar Gearhart, P. J., Caron, D. M., Douglas, R., Bruderer, U., Rittenberg, M. & Hood, L. (1987) The major role of somatic mutation in antibodies is to increase affinity. (In preparation). Google Scholar Gearhart, P. J., Johnson, N. D, Douglas, R. & Hood, L. (1981) IgG antibodies to phospho-rylcholine exhibit more diversity than their IgM counterparts. Nature 291, 29. 10.1038/291029a0 CASPubMedWeb of Science®Google Scholar Gershenfeld, H. K., Tsukamoto, A., Weissman, I. L. & Joho, R. (1981) Somatic diversification is required to generate the VK genes of MOPC 511 and MOPC 167 myeloma proteins. Proc. Natl. Acad. Sci. USA 78, 7674. 10.1073/pnas.78.12.7674 CASPubMedWeb of Science®Google Scholar Golding, G. B., Gearhart, P. J. & Glickman, B. W. (1987) Patterns of somatic mutations in immunoglobulin variable genes. Genetics 115, 169. CASPubMedWeb of Science®Google Scholar Gorski, J., Rollini, P. & Mach, B. (1983) Somatic mutations of immunoglobulin variable genes are restricted to the rearranged V gene. Science 220, 1179. 10.1126/science.6857243 CASPubMedWeb of Science®Google Scholar Griffiths, G. M., Berek, C, Kaartinen, M. & Milstein, C. (1984) Somatic mutation and the maturation of immune response to 2-phenyl oxazolone. Nature 312, 271. 10.1038/312271a0 CASPubMedWeb of Science®Google Scholar Grossman, L. (1981) Enzymes involved in the repair of damaged DNA. Arch. Biochem. Biophys. 211, 511. 10.1016/0003-9861(81)90485-9 CASPubMedWeb of Science®Google Scholar Hartman, A. B. & Rudikoff, S. (1984) VH genes encoding the immune response to β-(1,6)- galactan: somatic mutation in IgM molecules. EMBO J. 3, 3023. 10.1002/j.1460-2075.1984.tb02249.x CASPubMedWeb of Science®Google Scholar Herron, J. N. & Voss, E. W. (1983) Analysis of heterogeneous dissociation kinetics in polyclonal populations of rabbit anti-fluorescyl-IgG antibodies. Mol. Immunol. 20, 1323. 10.1016/0161-5890(83)90163-3 CASPubMedWeb of Science®Google Scholar Hood, L., Loh, E., Hubert, J., Barstad, P, Eaton, B., Early, P, Fuhrman, J., Johnson, N., Kronenberg, M. & Schilling, J. (1977) The structure and genetics of mouse immunoglobulins: An analysis of NZB myeloma proteins and sets of Balb/c myeloma proteins binding particular haptens. Cold Spring Harbor Symp. Quant. Biol. 41, 817. 10.1101/SQB.1977.041.01.092 PubMedWeb of Science®Google Scholar Imanishi-Kari, T, Rajnavolgyi, E., Takemori, T, Jack, R. S. & Rajewsky, K. (1979) The effect of light chain gene expression on the inheritance of an idiotype associated with primary anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies. Eur. J. Immunol. 9, 324. 10.1002/eji.1830090414 CASPubMedWeb of Science®Google Scholar Kaartinen, M., Griffiths, G. M., Markham, A. F. & Milstein, C. (1983) mRNA sequences define an unusually restricted IgG response to 2-phenyoxazolone and its early diversification. Nature 304, 320. 10.1038/304320a0 CASPubMedWeb of Science®Google Scholar Kaartinen, M., Pelkonen, J. & Makela, O. (1986) Several V genes participate in the early phenyloxazolone response in various combinations. Eur. J. Immunol. 16, 98. 10.1002/eji.1830160119 CASPubMedWeb of Science®Google Scholar Kim, S., Davis, M., Patten, P. & Hood, L. (1981) Antibody diversity: somatic hypermutation of rearranged VH genes. Cell 27, 573. 10.1016/0092-8674(81)90399-8 CASPubMedWeb of Science®Google Scholar Kocker, H. P., Berek, C. & Jaton, J. C. (1981) The immune response of Balb/c mice to phosphorylcholine is restricted to a limited number of VH and VL-isotypes. Mol. Immunol. 18, 1027. 10.1016/0161-5890(81)90018-3 PubMedWeb of Science®Google Scholar Kunkel, T. A. & Loeb, L. A. (1981) Fidelity of mammalian DNA polymerases. Science 213, 765. 10.1126/science.6454965 CASPubMedWeb of Science®Google Scholar Kwan, S.-P, Rudikoff, S., Seidman, J. G., Leder, R & Scharff, M. D. (1981) Nucleic acid and protein sequences of phosphocholine-binding light chains. J. Exp. Med. 153, 1366. 10.1084/jem.153.5.1366 CASPubMedWeb of Science®Google Scholar Lawler, A. M., Lin, P. S. & Gearhart, P. J. (1987) Adult B-cell repertoire is biased towards two VH genes that rearrange frequently in fetal pre-B cells. Proc. Natl. Acad. Sci USA (in press). 10.1073/pnas.84.8.2454 Web of Science®Google Scholar Livant, D., Blatt, C. & Hood, L. (1986) One heavy chain variable region gene segment subfamily in the Balb/c mouse countains 500-1000 or more members. Cell 47, 461. 10.1016/0092-8674(86)90603-3 CASPubMedWeb of Science®Google Scholar Manser, T, Huang, S. Y. & Gefter, M. L. (1984) Influence of clonal selection on the expression of immunoglobulin variable region genes. Science 226, 1283. 10.1126/science.6334361 CASPubMedWeb of Science®Google Scholar McKean, D., Huppi, K., Bell, M., Staudt, L., Gerhard, W. & Weigert, M. (1984) Generation of antibody diversity in the immune response of Balb/c mice to influenza virus hemagglutinin. Proc. Natl. Acad. Sci. USA 81, 3180. 10.1073/pnas.81.10.3180 CASPubMedWeb of Science®Google Scholar Nishi, M., Katoka, T. & Honjo, T. (1985) Preferential rearrangement of the immunoglohulin K chain joining region JKI and JK2 segments in mouse spleen DNA. Proc. Natl. Acad. Sci. USA 82, 6399. 10.1073/pnas.82.19.6399 CASPubMedWeb of Science®Google Scholar Pelkonen, J., Kaartinen, M. & Makela, O. (1986) Quantitative representation of two germ-line V genes in the early antibody response to 2-phenyl-oxazolone. Eur. J. Immunol. 16, 106. 10.1002/eji.1830160120 CASPubMedWeb of Science®Google Scholar Perlmutter, R. M., Crews, S. T, Douglas, R., Sorensen, G., Johnson, N., Nivera, N., Gearhart, P. J. & Hood, L. (1984) The generation of diversity in phosphorylcholine- binding antibodies. Adv. Immunol. 35, 1. 10.1016/S0065-2776(08)60572-6 CASPubMedWeb of Science®Google Scholar Pierce, J. W., Hudak, S. & Claflin, J. L. (1984) The role of a novel VH sequence (VII) in the formation of anti-phosphocholine antibodies. Mol. Immunol. 21, 159. 10.1016/0161-5890(84)90131-7 CASPubMedWeb of Science®Google Scholar Reth, M., Hammerling, G. J. & Rajewsky, K. (1978) Analysis of the repertoire of anti-NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response. Eur. J. Immunol. 8, 393. 10.1002/eji.1830080605 CASPubMedWeb of Science®Google Scholar Reth, M., Imanishi-Kari, T. & Rajewsky, K. (1979) Analysis of the repertoire of anti- (4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in C57BI/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti-idiotope antibodies. Eur. J. Immunol. 9, 1004. 10.1002/eji.1830091216 CASPubMedWeb of Science®Google Scholar Ripley, L. S. & Glickman, B. W. (1983) Unique self-complementarity of palindromic sequences provides DNA structural intermediates for mutation. Cold Spring Harbor Symp. Quant. Biol. 43, 851. 10.1101/SQB.1983.047.01.097 Google Scholar Rocca-Serra, J., Tonnelle, C. & Fougereau, M. (1983) Two monoclonal antibodies against different antigens using the same VH germ-line gene. Nature 304, 353. 10.1038/304353a0 CASPubMedWeb of Science®Google Scholar Rodwell, J. D, Gearhart, P. J. & Karush, F. (1983) Restriction in IgM expression. IV. Affinity analysis of monoclonal anti-phosphorylcholine antibodies. J. Immunol. 130, 313. CASPubMedWeb of Science®Google Scholar Rudikoff, S. & Potter, M. (1976) Size differences among immunoglobulin heavy chains from phosphorylcholine-binding proteins. Proc. Natl. Acad. Sci. USA 73, 2109. 10.1073/pnas.73.6.2109 CASPubMedWeb of Science®Google Scholar Rudikoff, S. & Potter, M. (1978) K chain variable region from Ml67, a phosphorylcholine binding myeloma protein. Biochemistry 17, 2703. 10.1021/bi00607a001 CASPubMedWeb of Science®Google Scholar Rudikoff, S., Yoshinori, S., Padlan, E., Davies, D. & Potter, M. (1981) Kappa chain structure from a crystallized murine Fab': role of joining segment in hapten binding. Mol. Immunol. 18, 705. 10.1016/0161-5890(81)90062-6 CASPubMedWeb of Science®Google Scholar Seidman, M. M., Bredberg, A., Seetharam, S. & Kraemer, K. H. (1987) Clustered point mutations in a shuttle vector propagated in human cells: implications for immunoglobulin hypervariability. (submitted). Google Scholar Seising, E. & Storb, U. (1981) Somatic mutation of immunoglobulin light-chain variable-region genes. Cell 25, 47. 10.1016/0092-8674(81)90230-0 PubMedWeb of Science®Google Scholar Stavnezer, J., McGrath, J. P, Slavin, K. J., Li, R., Li, Y, Herz, R. & Alhadeff, B. (1981) The numbers and rearrangements of genes in the T15 K group. In: ICN-UCLA Symposia on Molecular and Cellular Biology 20, 65. CASGoogle Scholar Vogel, F. (1970) Spontaneous mutation in man. In: Chemical Mutagenesis in mammals and man, eds. F. Vogel & G. Roehrborn, p. 16. 10.1007/978-3-642-85874-1_2 Google Scholar Springer-Verlag, Berlin. Wabl, M., Burrows, P. D., von Gabain, A. & Steinberg, C. (1985) Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line. Proc. Natl. Acad. Sci. USA 82, 479. 10.1073/pnas.82.2.479 PubMedWeb of Science®Google Scholar Wysocki, L., Manser, T. & Gefter, M. L. (1986) Somatic evolution of variable region structures during an immune response. Proc. Natl. Acad. Sci. USA 83, 1847. 10.1073/pnas.83.6.1847 CASPubMedWeb of Science®Google Scholar Yancopoulos, G. D., Desiderio, S. V., Paskind, M., Kearney, J. R, Baltimore, D. & Alt, R W. (1984) Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature 311, 727. 10.1038/311727a0 CASPubMedWeb of Science®Google Scholar Citing Literature Volume96, Issue1April 1987Pages 59-74 ReferencesRelatedInformation