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BIBTEX RIS

Pharmacology and Toxicology of Nav1.5-Class 1 Antiarrhythmic Drugs

2014; Elsevier BV; Volume: 6; Issue: 4 Linguagem: Inglês

10.1016/j.ccep.2014.07.003

ISSN

1877-9190

Autores

Dan M. Roden,

Tópico(s)

Analytical Methods in Pharmaceuticals

Resumo

Although cardiac sodium channel blocking drugs can exert antiarrhythmic actions, they can also provoke life-threatening arrhythmias through a variety of mechanisms. This review addresses the way in which drugs interact with the channel, and how these effects translate to clinical beneficial or detrimental effects. A further understanding of the details of channel function and of drug-channel interactions may lead to the development of safer and more effective antiarrhythmic therapies.

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