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THE CORRELATION OF SERUM CARBOHYDRATE ANTIGEN 19-9 WITH BENIGN HYDRONEPHROSIS

2002; Lippincott Williams & Wilkins; Volume: 167; Issue: 1 Linguagem: Inglês

10.1016/s0022-5347(05)65372-4

1527-3792

Kazumi Suzuki, Osamu Muraishi, Akihiko Tokue,

Glycosylation and Glycoproteins Research

No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Jan 2002THE CORRELATION OF SERUM CARBOHYDRATE ANTIGEN 19-9 WITH BENIGN HYDRONEPHROSIS KAZUMI SUZUKI, OSAMU MURAISHI, and AKIHIKO TOKUE KAZUMI SUZUKIKAZUMI SUZUKI , OSAMU MURAISHIOSAMU MURAISHI , and AKIHIKO TOKUEAKIHIKO TOKUE View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)65372-4AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: High serum carbohydrate antigen 19-9 in patients with hydronephrosis but without malignant disease is reportedly rare but to our knowledge the clinical features of hydronephrosis that affect this level have not yet been clarified. We examined the correlation of serum carbohydrate antigen 19-9 with hydronephrosis status in patients with benign hydronephrosis. Materials and Methods: We used 123 serum samples from 68 patients with and 55 without hydronephrosis. All patients enrolled in this study had no malignant disease. Serum carbohydrate antigen 19-9 was measured by immunoradiometric assay and that level was correlated with clinical factors. Results: Serum carbohydrate antigen 19-9 in patients with hydronephrosis was significantly higher than in those without hydronephrosis (p <0.0001). The serum level was elevated to greater than 37 units per ml. in 25% of the patients with but in only 1.8% of those without hydronephrosis. In the hydronephrosis group the clinical features that significantly correlated with the increased serum level were bilateral hydronephrosis, urinary tract infection, proteinuria, increased serum blood urea nitrogen, severe urinary tract occlusion and high grade hydronephrosis. Conclusions: Serum carbohydrate antigen 19-9 was significantly elevated in patients with benign hydronephrosis. Hydronephrosis causes false-positive results when screening for malignant disease by serum carbohydrate antigen 19-9 measurement. References 1 : Colorectal carcinoma antigens detected by hybridoma antibodies. Somatic Cell Genet1979; 5: 957. Google Scholar 2 : Specific antigen in serum of patients with colon carcinoma. Science1981; 212: 53. Google Scholar 3 : Radioimmunometric assay for a monoclonal antibody-defined tumor marker, CA19–9. Clin Chem1983; 29: 549. Google Scholar 4 : Tissue polypeptide specific antigen (TPS), a marker for differentiation between pancreatic carcinoma and chronic pancreatitis. A comparative study with CA19–9.. Cancer2000; 89: 83. Google Scholar 5 : A new strategy for the application of CA19–9 in the differentiation of pancreaticobiliary cancer: analysis using a receiver operating characteristic curve. Am Coll Gastroenterol1999; 94: 1941. Google Scholar 6 : Gastrointestinal cancer-associated in immunoperoxidase assay. Cancer Res1982; 42: 4820. Google Scholar 7 : Distribution of monoclonal antibody-defined monosialoganglioside in normal and cancerous human tissues: an immunoperoxidase study. Hybridoma1983; 2: 219. Google Scholar 8 : Immunohistochemical distribution of CA19–9 in normal and tumor tissues of the kidney. Urol Int1990; 45: 1. Google Scholar 9 : A case of transient sharp elevation of blood CA19–9 after percutaneous nephrostomy for hydronephrosis due to ureteral stone. Iryo1992; 46: 844. Google Scholar 10 : A case of hydronephrosis caused by renal stones with elevated serum level of CA19–9 and CA125. Acta Urol Jpn1994; 40: 885. Google Scholar 11 : Hydronephrosis with high level CA19–9 in serum: a case report. Hinyoki Geka1995; 8: 651. Google Scholar 12 : A case of severe hydronephrosis with significantly elevated serum CA19–9. Rinsho Hinyokika1995; 49: 855. Google Scholar 13 : A case of hydronephrosis with high level of serum Span-1 antigen and CA19–9. Acta Urol Jpn1996; 42: 51. Google Scholar 14 : Hydronephrosis and hydroureter with extremely high levels of serum carbohydrate antigens 19–9 and span-1: a case report. J Urol1996; 155: 1386. Link, Google Scholar 15 : Giant hydronephrosis due to a ureteral stone, and elevated serum levels of CA19–9. Intern Med1999; 38: 887. Google Scholar 16 : A case of pyonephrosis caused by ureteral stones with elevated serum levels of CA19–9. Acta Urol Jpn1999; 45: 629. Google Scholar 17 : A case of hydronephrosis presented high serum CA19–9. Rinsho Hinyokika2001; 55: 477. Google Scholar 18 : Values of CA19–9 in the serum, pure pancreatic juice, and aspirated pancreatic material in the diagnosis of malignant pancreatic tumor. Cancer1985; 56: 2669. Google Scholar 19 : The effect of benign and malignant liver disease on the tumour markers CA19–9 and CEA. Ann Clin Biochem1998; 35: 99. Google Scholar 20 : Serum CA19–9 levels in patients with hepatocellular carcinoma or cirrhosis. Ital J Gastroenterol1985; 17: 288. Google Scholar 21 : Elevated serum levels of tumor marker CA19–9 in acute cholangitis. Dig Dis Sci1988; 33: 1223. Google Scholar 22 : Tumor markers in bronchogenic carcinoma. Superiority of tissue polypeptide antigen to carcinoembryonic antigen and carbohydrate antigen determinant 19–9. Cancer1987; 60: 42. Google Scholar 23 : Elevated of serum CA19–9 levels in benign disease. Intern Med1999; 38: 840. Google Scholar 24 : Sensitivity of gray scale ultrasound in detecting urinary tract obstruction. AJR Am J Roentgenol1978; 130: 731. Google Scholar 25 : Measurement of a monoclonal-antibody-defined antigen (CA19–9) in the sera of patients with malignant and nonmalignant disease. Cancer1985; 56: 277. Google Scholar 26 : Comparative studies of DU-PAN-2, carcinoembryonic antigen, and CA19–9 in the serum and bile of patients with pancreatic and biliary tract disease: evaluation of the influence of obstructive jaundice. Am Coll Gastroenterol1990; 85: 1370. Google Scholar 27 : A giant renal cyst in a young man with increased carbohydrate antigen 19–9 in serum and cystic fluid. J Urol2001; 165: 509. Abstract, Google Scholar 28 : Elevated tumour marker CA19–9: clinical interpretation and influence of obstructive jaundice. Eur J Surg Oncol2000; 26: 474. Google Scholar 29 : Distribution of CA19–9 in adenocarcinoma and transitional cell carcinomas. Am J Clin Pathol1993; 99: 726. Google Scholar 30 : Renal pelvic and ureteral cancer with extremely high serum level of carbohydrate antigen 19–9 (CA19–9): A case report. Nishinihon J Urol2000; 62: 659. Google Scholar 31 : A case of bronchogenic cyst with high production of antigen CA19–9. Cancer1989; 63: 1994. Google Scholar From the Department of Urology, Jichi Medical School, Tochigi, Japan© 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byKajbafzadeh A, Elmi A, Talab S, Emami H, Esfahani S and Saeedi P (2018) Urinary and Serum Carbohydrate Antigen 19-9 as a Biomarker in Ureteropelvic Junction Obstruction in ChildrenJournal of Urology, VOL. 183, NO. 6, (2353-2360), Online publication date: 1-Jun-2010.Suzuki K (2018) Re: Serum Tumor Markers May Predict Overall and Disease Specific Survival in Patients With Clinically Organ Confined Invasive Bladder CancerJournal of Urology, VOL. 179, NO. 6, (2481-2481), Online publication date: 1-Jun-2008. Volume 167Issue 1January 2002Page: 16-20 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.Keywordshydronephrosiskidneytumor markers, biologicalCA-19–9MetricsAuthor Information KAZUMI SUZUKI More articles by this author OSAMU MURAISHI More articles by this author AKIHIKO TOKUE More articles by this author Expand All Advertisement PDF downloadLoading ...