Beta 2 -microglobulin excretion as an index of renal tubular disorders with special reference to endemic B alkan nephropathy.
1973; National Institutes of Health; Volume: 81; Issue: 6 Linguagem: Inglês
Autores
Philip W. Hall, Miodrag Vasiljevič,
Tópico(s)Gout, Hyperuricemia, Uric Acid
ResumoAbstract A simple immunodiffusion test for β 2 -microglobulin has been developed which will measure concentrations above 16 μg per milliliter. This concentration is readily achieved in the urine in conditions associated with primary renal tubular disorders but not in the normal urine or that from patients with glomerular diseases. The method was used to assay urine of patients with established pathology, and in a routine screening survey of two populations, a United States random patient group and a random population from an area where the tubular disorder of Balkan nephropathy is endemic. The specificity and sensitivity of the test were compared to other tests of proteinuria. β 2 -Microglobulin proteinuria can be detected in untreated urine from individuals whose urines are negative for protein by dipstick and sulfosalicylic acid screening methods. The data show that this method is highly selective and more sensitive than the other methods tested in screening populations for the presence of tubular proteinuria.
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