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An In Vitro Evaluation of a New Plasticizer for Polyvinylchloride Medical Devices

1980; Wiley; Volume: 20; Issue: 4 Linguagem: Inglês

10.1046/j.1537-2995.1980.20480260277.x

1537-2995

May S. Jacobson, Sherwin V. Kevy, Robertson Parkman, John S. Wesolowski,

Effects and risks of endocrine disrupting chemicals

The rate of Hatcol-200 (H-200) leaching from polyvinylchloride (PVC) by serum is one-hundredth that of di-2-ethylhexyl phthalate (DEHP) as determined by radioassay. There is a proportional decrease in leachability of DEHP but not of H-200 as the plasma proteins are diluted. Saline extracts of DEHP demonstrated a low but progressive rate of leaching with an accumulation of 11 microgram/ml after seven weeks whereas H-200 showed only a constant residue of 0.35 microgram/ml. Normal human serum incubated for three weeks at 37 C with PVC strips plasticized with DEHP produced significant growth-inhibition of human diploid fibroblasts. Human serum incubated in an identical manner with PVC plasticized with H-200 for up to four weeks demonstrated no effect on tissue culture. These studies indicate that H-200 deserves further evaluation as a replacement for DEHP in PVC biomedical devices.