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Adverse effect of verapamil in myasthenia gravis

1992; Wiley; Volume: 15; Issue: 3 Linguagem: Inglês

10.1002/mus.880150321

1097-4598

Michael Swash, David A. Ingram,

Peripheral Neuropathies and Disorders

Abstract Verapamil, a class IV anti‐arrhythmic drug that blocks voltage‐dependent calcium channels in cardiac and smooth muscle, also has effects on presynaptic and postsynaptic voltage‐dependent calcium channels at the neuromuscular junction. In a postoperative patient with pre‐existent myasthenia gravis, oral verapamil caused a marked exacerbation in myasthenic weakness.