Portal de Periódicos da CAPES

A Metal–Collagen Peptide Framework for Three‐Dimensional Cell Culture

2009; Wiley; Volume: 48; Issue: 42 Linguagem: Inglês

10.1002/anie.200902375

1521-3773

Marcos M. Pires, David E. Przybyla, Jean Chmielewski,

Marine Biology and Environmental Chemistry

It won′t overstay its welcome: Metal ions trigger the rapid assembly of a triple-helical collagen-based peptide with ligands at the ends and center into a fibrous three-dimensional mesh under physiological conditions (see picture). Importantly for applications in regenerative medicine, a mild chelating agent causes rapid disassembly of the mesh. Human endothelial cells were readily encapsulated and cultured within the collagen-peptide network. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.