Comparative efficacy of betamethasone/clioquinol (Betnovate-C) cream and betamethasone/fusidic acid (Fucibet) cream in the treatment of infected hand eczema
1998; Informa; Volume: 9; Issue: 1 Linguagem: Inglês
10.3109/09546639809160683
ISSN1471-1753
AutoresVa Hill, Edward S. Wong, Mf Corbett, A. P. Menday,
Tópico(s)Orthopedic Infections and Treatments
ResumoAbstractThe efficacy, tolerability and acceptability of betamethasone valerate 0.1%/fusidic acid 2% cream and betamethasone valerate 0.1%/clioquinol 3% cream were compared in 120 patients of either sex, aged 18 years or over, with a clinical diagnosis of infected hand eczema. Both creams were applied twice daily for up to 4 weeks. Assessments were made by the investigator and by the patient at baseline and at 1, 2 and 4 weeks. Swabs were taken for bacteriological culture at baseline and at the end of treatment. Overall, both creams were similarly effective clinically, with 57.9% of patients given betamethasone/clioquinol and 60.4% of patients given betamethasone/fusidic acid responding (NS; 95% confidence interval for difference -16.1, 21.2). However, betamethasone/fusidic acid cream gave a significantly better bacteriological response (P< 0.005). Both treatments were well tolerated. Betamethasone/fusidic acid cream was considered by the patients to be a significantly more cosmetically acceptable treatment (P<0.0001).Key Words: EczemaTreatmentBetamethasone valerateClioquinolFusidic acid
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