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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Antimicrobial effectiveness of maleimides on fungal strains isolated from onychomycosis

2006; Instituto de Tecnologia do Paraná (Tecpar); Volume: 49; Issue: 4 Linguagem: Inglês

10.1590/s1516-89132006000500016

ISSN

1678-4324

Autores

Carla Wanderley Gayoso, Edeltrudes de Oliveira Lima, Evandro Leite de Souza, Valdir Cechinel Filho, Vinícius Nogueira Trajano, Fillipe de Oliveira Pereira, Igara Oliveira Lima,

Tópico(s)

Phytochemical compounds biological activities

Resumo

This study aimed to analyze the effectiveness of maleimides as inhibitors on the growth of fungal strains isolated from onychomycosis by the solid medium diffusion procedure. The results showed a promising antifungical activity of the assayed maleimides with formation of fungal growth inhibition halos oscillating between diameter 10 and 23mm. MIC was 100µg/mL for 3,4-dichloro-N-phenyl-methyl-maleimide and 3,4-dichloro-N-phenyl-propil-maleimide and 200µg/mL for 3,4-dichloro-N-phenyl-maleimide, 3,4-dichloro-N-phenyl-ethyl-maleimide and 3,4-dichloro-N-phenyl-buthyl-maleimide.

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