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Prognostic Impact of Pregnancy After Breast Cancer According to Estrogen Receptor Status: A Multicenter Retrospective Study

2012; Lippincott Williams & Wilkins; Volume: 31; Issue: 1 Linguagem: Inglês

10.1200/jco.2012.44.2285

1527-7755

Hatem A. Azim, Niels Kroman, Marianne Paesmans, Shari Gelber, Nicole Rotmensz, Lieveke Ameye, Leticia De Mattos‐Arruda, Barbara Pistilli, Álvaro Pinto, Maj‐Britt Jensen, Octavi Córdoba, Evandro de Azambuja, Aron Goldhirsch, Martine Piccart, Fedro A. Peccatori,

Childhood Cancer Survivors' Quality of Life

We questioned the impact of pregnancy on disease-free survival (DFS) in women with history of breast cancer (BC) according to estrogen receptor (ER) status.A multicenter, retrospective cohort study in which patients who became pregnant any time after BC were matched (1:3) to patients with BC with similar ER, nodal status, adjuvant therapy, age, and year of diagnosis. To adjust for guaranteed time bias, each nonpregnant patient had to have a disease-free interval at least equal to the time elapsing between BC diagnosis and date of conception of the matched pregnant one. The primary objective was DFS in patients with ER-positive BC. DFS in the ER-negative cohort, whole population, and overall survival (OS) were secondary objectives. Subgroup analyses included DFS according to pregnancy outcome and BC-pregnancy interval. With a two-sided α = 5% and β = 20%, 645 ER-positive patients were required to detect a hazard ratio (HR) = 0.65.A total of 333 pregnant patients and 874 matched nonpregnant patients were analyzed, of whom 686 patients had an ER-positive disease. No difference in DFS was observed between pregnant and nonpregnant patients in the ER-positive (HR = 0.91; 95% CI, 0.67 to 1.24, P = .55) or the ER-negative (HR = 0.75; 95% CI, 0.51 to 1.08, P = .12) cohorts. However, the pregnant group had better OS (HR = 0.72; 95% CI, 0.54 to 0.97, P = .03), with no interaction according to ER status (P = .11). Pregnancy outcome and BC-pregnancy interval did not seem to impact the risk of relapse.Pregnancy after ER-positive BC does not seem to reduce the risk of BC recurrence.