Acanthosis Nigricans as a Risk Factor for Non-Insulin Dependent Diabetes Mellitus
1998; SAGE Publishing; Volume: 37; Issue: 2 Linguagem: Inglês
10.1177/000992289803700203
ISSN1938-2707
AutoresC. A. Stuart, Charles R. Gilkison, Michele Murphy Smith, Anna Marie Bosma, Bruce S. Keenan, Manubai Nagamani,
Tópico(s)Systemic Sclerosis and Related Diseases
ResumoThe prevalences of obesity and of non-insulin dependent diabetes mellitus (NIDDM) have increased in the United States population over the past two decades, and thus diabetes preven tion has become a major concern of public health agencies such as the National Institutes of Health. Identification of individuals at risk for diabetes is an essential first step in designing and implementing intervention programs. Insulin resistance is the hallmark of the pathophysiology of NIDDM. Subjects with hyperinsulinemia, impaired glucose tolerance, or gestational diabetes are well accepted as being at high risk for diabetes. We propose that the easily identifiable skin lesion, acanthosis nigricans, is common in the major minority groups in the United States and that its presence is a surrogate for laboratory-determined hyperinsulinemia. Clin Pediatr. 1998;37:73-80
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