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BIBTEX RIS

Novel Terpenoids from Calocedrus macrolepis var. formosana

2011; Wiley; Volume: 8; Issue: 10 Linguagem: Inglês

10.1002/cbdv.201000237

ISSN

1612-1880

Autores

Chin‐Lin Hsieh, Mei‐Hwei Tseng, Ryh‐Nan Pan, Jang‐Yang Chang, Ching‐Chuan Kuo, Tzong‐Huei Lee, Yueh‐Hsiung Kuo,

Tópico(s)

Synthetic Organic Chemistry Methods

Resumo

Abstract Calocetriol ( 1 ), diacetylcalocediol ( 2 ), and ferrugimenthenol ( 3 ) were isolated from the bark of Calocedrus macrolepis var. formosana. Among them, 1 and 2 are secoabietane‐type diterpenoids, and 3 , with a novel C 20 C 10 skeleton, is classified as a meroterpenoid. The structures of 1 – 3 were elucidated by spectroscopic analyses, and their biological activities were also evaluated. Compound 3 exhibited significant cytotoxic activity against human oral epidermoid carcinoma KB cells with an IC 50 value of 9.0±0.1 μ M .

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