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Treatment Outcome and Mortality among Patients with Multidrug-resistant Tuberculosis in Tuberculosis Hospitals of the Public Sector

2010; Korean Academy of Medical Sciences; Volume: 26; Issue: 1 Linguagem: Inglês

10.3346/jkms.2011.26.1.33

1598-6357

Doosoo Jeon, Dong Ok Shin, Seung Kyu Park, Jeong Eun Seo, Hae Sook Seo, Young Soo Cho, Jun Young Lee, Dae Yun Kim, Suck Jun Kong, Yun Seong Kim, Tae Sun Shim,

Infectious Diseases and Tuberculosis

Treatment Outcome and Mortality among Patients with Multidrug-resistant Tuberculosis in Tuberculosis Hospitals of the Public SectorThis study was conducted to evaluate treatment outcome, mortality, and predictors of both in patients with multidrug-resistant tuberculosis (MDR-TB) at 3 TB referral hospitals in the public sector of Korea.We included MDR-TB patients treated at 3 TB referral hospitals in 2004 and reviewed retrospectively their medical records and mortality data.Of 202 MDR-TB patients, 75 (37.1%)had treatment success and 127 (62.9%) poor outcomes.Default rate was high (37.1%,75/202), comprising 59.1% of poor outcomes.Male sex (adjusted odds ratio [aOR], 2.91; 95% confidence interval [CI], 1.13-7.49),positive smear at treatment initiation (aOR, 5.50; 95% CI, 1.22-24.90),and extensively drug-resistant TB (aOR, 10.72; 95% CI, were independent predictors of poor outcome.The allcause mortality rate was 31.2% (63/202) during the 3-4 yr after treatment initiation.In conclusion, the treatment outcomes of patients with MDR-TB at the 3 TB hospitals are poor, which may reflect the current status of MDR-TB in the public sector of Korea.A more comprehensive program against MDR-TB needs to be integrated into the National Tuberculosis Program of Korea.