Chronic demyelinating polyneuropathy in graft‐versus‐host disease following allogeneic bone marrow transplantation
2002; Wiley; Volume: 22; Issue: 1 Linguagem: Inglês
10.1046/j.0919-6544.2002.00419_22_1.x
ISSN1440-1789
AutoresToshiko Nagashima, Fumie Sato, Takayo Chuma, Yukio Mano, Isao Sasaki, Masamitsu Mori, Toshio Higa, Nobuo Masauji, Masaharu Kasai, Yasuko Orba, Toshiya Shinohara, Kazuo Nagashima,
Tópico(s)Multiple Sclerosis Research Studies
ResumoIn recent years a novel problem has arisen in organ transplantation medicine, namely GVHD. The nervous system has been involved mainly at the level of the CNS and this can lead to a serious outcome for the patient. In rare cases, peripheral nerves may be affected and show acute or chronic polyneuropathy. Here a case is reported of polyneuropathy associated with chronic GVHD. A 32‐year‐old man, suffering from chronic GVHD following an allogeneic bone marrow transplantation (BMT) for malignant lymphoma at the age of 25, developed a motor dominant polyneuropathy 5 years later. Electrophysiologic studies demonstrated the demyelinating type of polyneuropathy. Biopsy specimens from skin and skeletal muscle disclosed perivascular lymphocytic infiltrates expressing T‐cell markers. The sural nerve showed a loss of myelinated nerve fibers with epineurial fibrosis and rare occurrence of T cells, but without obvious vasculitic changes. The present case suggested that polyneuropathy could develop in association with chronic GVHD in some patients with a longstanding disease course.
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