Estrogen receptor expression in papillary urothelial carcinoma of the bladder and ovarian transitional cell carcinoma.
2005; American Medical Association; Volume: 129; Issue: 2 Linguagem: Inglês
10.1043/1543-2165(2005)129 2.0.co;2
ISSN1543-2165
AutoresPhilip R. Croft, Sarah Lathrop, Richard M. Feddersen, Nancy E. Joste,
Tópico(s)Urological Disorders and Treatments
ResumoAbstract Context.—Relatively little is known about estrogen receptor (ER) expression in papillary urothelial carcinoma (PUC) of the bladder. Greater understanding of this feature of PUCs could aid with the treatment and identification of the origin of metastases, particularly with relation to the morphologically similar entity of ovarian transitional cell carcinoma (TCC). Objective.—To assess the presence of ERs in PUC of the bladder, its metastases, and ovarian TCC. Design.—Formalin-fixed, paraffin-embedded archival tissue from 92 primary bladder PUCs, 11 PUC metastases, and 11 primary or metastatic ovarian TCCs was immunostained with a monoclonal antibody against the human ER β-molecule. The ER-positive and ER-negative tumors were compared by the patients' sex and age, tumor grade, and the presence or absence of invasion. Statistical analysis was performed on the PUC results, first defining a positive result as staining of at least 10% of nuclei and then repeated using any percentage of staining as a po...
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