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Epidemic characteristics of hand, foot, and mouth disease in southern China, 2013: Coxsackievirus A6 has emerged as the predominant causative agent

2014; Elsevier BV; Volume: 69; Issue: 3 Linguagem: Inglês

10.1016/j.jinf.2014.04.001

1532-2742

Jinlin Li, Jing Yuan, Fan Yang, Zhìqiáng Wú, Yongfeng Hu, Ying Xue, Boping Zhou, Qi Jin,

T-cell and Retrovirus Studies

Since the large-scale outbreak of HFMD in 2008 in China, millions of cases have been reported annually across many provinces, which poses a significant public health threat. Enterovirus (EV)-71 and Coxsackievirus (CV)-A16 are regarded as the predominant etiological agents for HFMD in China and are responsible for more than 80% of HFMD cases.1 Recently, CV-A6 has attracted more attention due to its dominant role in HFMD outbreaks in different countries worldwide.2–10 In China, only sporadic CV-A6 associated cases have been reported, though CV-A6 has been implicated in HFMD for years.