Histamine-releasing factors and inhibitors: Historical perspectives and possible implications in human illness
1991; Elsevier BV; Volume: 88; Issue: 5 Linguagem: Inglês
10.1016/0091-6749(91)90170-s
ISSN1097-6825
AutoresJ. A. Grant, R. Alam, M LETTBROWN,
Tópico(s)Asthma and respiratory diseases
ResumoThe initiation of allergic reactions with the bridging of surface-bound IgE antibodies on mast cells and basophils by allergens is well recognized.However, it is clear that other factors most likely play a role in regulating these cells.A number of cytokines have been ident$ed that modulate the secretory response of mast cells and basophils.Among the well-characterized cytokines, interleukin-3 and connective tissue-activating peptide Ill (or its degradation product, neutrophil-activating peptide 2) can increase the secretory response, whereas interleukin-8 specifically inhibits the response to cytokines.Additional factors are currently under investigation.Preliminary studies suggest an important role for these histamine-releasing factors in atopic disorders, as well as in other conditions in which an IgE-dependent mechanism is not demonstrable.Furthermore, these cytokines may modulate the response of basophils and mast cells in physiologic conditions, such as tissue repair and host defense.(J ALLERGY CUN
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