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Assignment of the appaloosa coat colour gene ( LP ) to equine chromosome 1

2004; Wiley; Volume: 35; Issue: 2 Linguagem: Inglês

10.1111/j.1365-2052.2004.01113.x

1365-2052

Robert Terry, S. Archer, Samantha A. Brooks, D Bernoco, Ernest Bailey,

Phytochemicals and Antioxidant Activities

Summary A single autosomal dominant locus, leopard complex ( LP ) controls the presence of appaloosa pigmentation patterns in the horse. The causative gene for LP is unknown. This study was undertaken to map LP in the horse. Two paternal half sib families segregating for the LP locus and including a total of 47 offspring were used to perform a genome scan which localized LP to horse chromosome 1 (ECA1). LP was linked to ASB 08 (LOD = 9.99 at Θ = 0.02) and AHT 21 (LOD = 5.03 at Θ = 0.14). To refine the map position of LP , eight microsatellite markers on ECA1 ( UM 041, LEX 77, 1CA 41, TKY 374, COR 046, 1CA 32, 1CA 43, and TKY 002) were analysed in the two half sib families. Results from this linkage analysis showed LP was located in the interval between ASB 08 and 1 CA 43. Tight junction protein ( TJP 1), which lies within the LP interval on ECA1, was used to determine the homologous chromosomes in humans (HSA15) and mice (mouse chromosome 7). We propose that the pink eyed dilution ( p ) gene and transient receptor potential cation channel subfamily M, member 1 ( TRPM 1) are positional candidate genes for LP .