Aqueous Flow is Reduced by the Alpha-adrenergic Agonist, Apraclonidine Hydrochloride (ALO 2145)
1988; Elsevier BV; Volume: 95; Issue: 9 Linguagem: Inglês
10.1016/s0161-6420(88)33038-1
ISSN1549-4713
AutoresN. Ziai Gharagozloo, Susan J. Relf, Richard F. Brubaker,
Tópico(s)Molecular spectroscopy and chirality
ResumoApraclonidine hydrochloride (ALO 2145), a clonidine derivative that does not cross the blood-brain barrier, was applied topically to one eye of each of 20 normal human subjects. The rate of aqueous humor flow and the permeability of the blood-aqueous barrier were measured by fluorophotometry. Four hours after administration, the flow rate in the apraclonidine-treated eyes was 35% lower than that measured in the control eyes. Three hours after instillation, the intraocular pressure (IOP) was 34% lower in the apraclonidine-treated eyes when compared with control eyes. Both these differences were statistically significant. The drug had little, if any, effect on blood-aqueous permeability.
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