Portal de Periódicos da CAPES

Copper-Mediated N-Alkynylation of Carbamates, Ureas, and Sulfonamides. A General Method for the Synthesis of Ynamides

2003; American Chemical Society; Volume: 5; Issue: 21 Linguagem: Inglês

10.1021/ol035647d

1523-7060

Joshua R. Dunetz, Rick Danheiser,

Catalytic Alkyne Reactions

A general amination strategy for the N-alkynylation of carbamates, sulfonamides, and chiral oxazolidinones and imidazolidinones is described. A variety of substituted ynamides are available by deprotonation of amides with KHMDS followed by reaction with CuI and an alkynyl bromide.