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Plant stanol ester margarine lowers serum total and low-density lipoprotein cholesterol concentrations of healthy children: The STRIP project

2000; Elsevier BV; Volume: 136; Issue: 4 Linguagem: Inglês

10.1016/s0022-3476(00)90014-3

1097-6833

Anne Tammi, Tapani Rönnemaa, Helena Gylling, Leena Rask-Nissilä, Jorma Viikari, Juhani Tuominen, Kari Pulkki, Olli Simell,

Fatty Acid Research and Health

Objective: To investigate cholesterol-lowering efficacy and safety of plant stanol ester margarine in healthy 6-year-old children already consuming a low-saturated-fat, low-cholesterol diet. Study design: Eighty-one intervention children from the STRIP project, a randomized prospective trial aimed at reducing exposure of young children to the known environmental atherosclerosis risk factors, were recruited to this double-blind crossover study at 6 years of age. In randomized order the families were advised to replace daily 20 g of the child's dietary fat intake with plant stanol ester margarine or control margarine for 3 months. The washout period lasted 6 weeks. Statistical analysis was performed according to intention-to-treat principle with analysis of variance for crossover design. Results: The mean daily plant stanol ester margarine consumption was 18.2 g (1.5 g plant stanol). The well-tolerated plant stanol ester margarine reduced serum total and low-density lipoprotein cholesterol concentrations by 5.4% and 7.5%, respectively (P =.0001 for both). The serum high-density lipoprotein cholesterol and triglyceride concentrations and α-tocopherol to low-density lipoprotein cholesterol ratio remained unchanged. The serum β-carotene to low-density lipoprotein cholesterol ratio decreased by 19% (P =.003). Conclusion: Plant stanol ester margarine significantly diminishes serum total and low-density lipoprotein cholesterol concentration without adverse clinical effects in healthy children who already consume a low-saturated-fat, low-cholesterol diet but decreases the serum β-carotene to low-density lipoprotein cholesterol ratio.(J Pediatr 2000;136:503-10)