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The Epidemiology of Renal Cell Carcinoma

2006; Lippincott Williams & Wilkins; Volume: 176; Issue: 6 Linguagem: Inglês

10.1016/j.juro.2006.07.130

1527-3792

Loren Lipworth, Robert E. Tarone, Joseph K. McLaughlin,

Renal and related cancers

No AccessJournal of UrologyReview article1 Dec 2006The Epidemiology of Renal Cell Carcinoma Loren Lipworth, Robert E. Tarone, and Joseph K. McLaughlin Loren LipworthLoren Lipworth International Epidemiology Institute, Rockville, Maryland Department of Preventive Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee , Robert E. TaroneRobert E. Tarone International Epidemiology Institute, Rockville, Maryland Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee , and Joseph K. McLaughlinJoseph K. McLaughlin International Epidemiology Institute, Rockville, Maryland Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee View All Author Informationhttps://doi.org/10.1016/j.juro.2006.07.130AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We identified and examined risk factors for renal cell cancer, some of which may explain in part the trends of steadily increasing incidence rates, particularly in black Americans. Materials and Methods: Epidemiological studies were identified through a MEDLINE® search of the literature through February 2006. A qualitative summary of the results of individual studies is presented. Results: Cigarette smoking and obesity are the most consistently established causal risk factors, accounting for about 20% and 30% of renal cell cancers, respectively. Hypertension appears to independently influence renal cell cancer risk. Neither acetaminophen nor other analgesics have been convincingly linked with renal cell cancer. With respect to diet a general protective effect of fruit and vegetable consumption is the only consistently reported finding. For occupational factors the weight of the evidence provides no consistent support for the hypotheses that renal cell cancer may be caused by asbestos, gasoline or trichloroethylene exposure. Self-reported family history is associated with 2 to 3-fold increases in risk and the major inherited forms of renal cell cancer together account for about 2% of this malignancy. Conclusions: A further reduction in cigarette smoking, and a decrease in the rates of obesity and hypertension would likely moderate the increasing incidence of renal cell cancer. 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Google Scholar © 2006 by American Urological AssociationFiguresReferencesRelatedDetailsCited byAkhavan A, Richards M, Shnorhavorian M, Goldin A, Gow K and Merguerian P (2018) Renal Cell Carcinoma in Children, Adolescents and Young Adults: A National Cancer Database StudyJournal of Urology, VOL. 193, NO. 4, (1336-1341), Online publication date: 1-Apr-2015.Bjurlin M, Cohn M, Freeman V, Lombardo L, Hurley S and Hollowell C (2018) Ethnicity and Smoking Status are Associated with Awareness of Smoking Related Genitourinary DiseasesJournal of Urology, VOL. 188, NO. 3, (724-728), Online publication date: 1-Sep-2012.Stafford H, Saltzstein S, Shimasaki S, Sanders C, Downs T and Robins Sadler G (2018) Racial/Ethnic and Gender Disparities in Renal Cell Carcinoma Incidence and SurvivalJournal of Urology, VOL. 179, NO. 5, (1704-1708), Online publication date: 1-May-2008. Volume 176Issue 6December 2006Page: 2353-2358 Advertisement Copyright & Permissions© 2006 by American Urological AssociationKeywordsepidemiologykidney neoplasmscarcinomarisk factorsrenal cellkidneyMetricsAuthor Information Loren Lipworth International Epidemiology Institute, Rockville, Maryland Department of Preventive Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee More articles by this author Robert E. Tarone International Epidemiology Institute, Rockville, Maryland Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee More articles by this author Joseph K. McLaughlin International Epidemiology Institute, Rockville, Maryland Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee More articles by this author Expand All Advertisement PDF downloadLoading ...