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Alcohol Consumption and Augmentation Index in Healthy Young Men: The ARYA Study

2005; Oxford University Press; Volume: 18; Issue: 6 Linguagem: Inglês

10.1016/j.amjhyper.2004.12.011

1941-7225

M VANTRIJP, Joline W. J. Beulens, Willem Jan W. Bos, Cuno Uiterwaal, D. E. Grobbee, H.F.J. Hendriks, M. L. Bots,

Liver Disease Diagnosis and Treatment

Light-to-moderate alcohol consumption is associated with a decreased risk of ischemic cardiovascular disease, whereas increased alcohol intake is related to hypertension and intracerebral hemorrhage. We studied the effect of alcohol consumption on the augmentation index (AIx), a measure of arterial wave reflection in a population of healthy young men. Three hundred twenty-nine men (mean age 28 years) from the Atherosclerosis Risk in Young Adults study (ARYA-study) were studied. The level of alcohol consumption and risk factors for cardiovascular disease were determined. The AIx was estimated by radial applanation tonometry using a Sphygmocor device. The relation between alcohol intake level and AIx was determined using linear regression models. There was a positive graded relation between alcohol intake and AIx. Subjects who did not drink, who drank 1 to 2 glasses/d, or who drank ≥3 glasses of alcohol/d had, respectively, a −0.6% (95% confidence interval [CI] −4.2, 3.0), 0.2% (95% CI −2.6, 2.9), and 3.4% (95% CI 0.2, 6.7) difference in AIx compared with very light drinkers ( 3 glasses/d had a 3.29% (95% confidence interval CI 0.01, 6.7) higher AIx compared with those consuming <1 glass/d. In a population of healthy young men, the heaviest drinkers had a significantly higher AIx. This finding supports the evidence that increased alcohol consumption is related to vascular damage at young age. Am J Hypertens 2005;18:792–796 © 2005 American Journal of Hypertension, Ltd.