Produção Nacional
Revisado por pares
Antibiotic Resistance in Streptococcus pneumoniae in Six Latin American Countries: 1993-1999 Surveillance
2001; Mary Ann Liebert, Inc.; Volume: 7; Issue: 4 Linguagem: Inglês
10.1089/10766290152773400
ISSN1931-8448
AutoresMaría Hortal, Marguerite Lovgren, Fernando de la Hoz, Clara Inés Agudelo, Maria-Cristina de C. Brandileone, Teresa Camou, Silvana Tadeu Casagrande, Elizabeth Castañeda, Alejandra Corso, Gabriela Echániz-Avilés, Juan Carlos Hormazábal, Julio Pace, Rosario Palacio, Gabriel Pérez-Giffoni, Raúl Ruvinsky, José Luis Di Fábio,
Tópico(s)Antibiotics Pharmacokinetics and Efficacy
ResumoThe impact of invasive pneumococcal invasive disease is increased by the emergence of antibiotic resistance. We report regional and temporal variations in antibiotic resistance for 4,105 invasive Streptococcus pneumoniae isolates collected from Latin American children or = 2 microg/ml), including 12.6% with MIC > or = 4 microg/ml, occurring primarily in serotypes 14 and 23F. Reduced susceptibility to third-generation cephalosporins was detected in 12.1% of the collection. Mexico had the highest proportion of reduced susceptibility to penicillin (51.6%) and to third-generation cephalosporins (22%), whereas Brazil had the lowest at 20.9% and 0.7%, respectively. Isolates cultured from patients with pneumonia were more likely to have reduced susceptibility to third-generation cephalosporins than isolates from patients with meningitis (p < 0.0001). Susceptibility to trimethoprim-sulfamethoxazole, chloramphenicol, erythromycin, and vancomycin was tested by disk diffusion for 2.899 isolates. Reduced susceptibility was observed for 45.6%, 11.5%, 6.9%, and 0%, respectively. Thirty-one percent of the strains were resistant to > or = 2 drugs. High levels of antibiotic resistance in Latin America emphasize the need for the development of and adherence to rational antibiotic use guidelines. On-going surveillance will monitor the impact of these programs.
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