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Effects of the food contaminant semicarbazide on testicular morphology of juvenile Wistar rats

2012; UNIVERSIDADE FEDERAL DE MINAS GERAIS; Volume: 64; Issue: 3 Linguagem: Inglês

10.1590/s0102-09352012000300037

1678-4162

António Ramos, Alfredo Manuel Franco Pereira, António Cabrita, Fernando Capela e Silva,

Effects and risks of endocrine disrupting chemicals

., 2004). Semicarbazide is also present in glass jars and bottles closed with metal lids sealed with plastic gaskets that are foamed using the azodicarbonamide as blowing agent (Opinion..., 2005). Azodicarbonamide is not listed as a permitted food additive in Council Directive 95/2/EC [European Parliament and Council Directive No. 95/2/EC of 20 February 1995 on food additives other than colors and sweeteners]; however, it semicarbazide hydrochloride (Sigmais used as a flour additive in some countries such as Canada, USA and Brazil owing to its dough-improving properties (de la Calle and Anklam, 2005). Recent studies proved that semicarbazide can also be formed in processed food such as coated poultry products and in bread prepared with azodicarbonamide-containing flour (de la Calle and Anklam, 2005). The toxicity of semicarbazide is not well understood (Opinion..., 2005 and Nestmann