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Drug Resistance of Staphylococci

1971; Wiley; Volume: 15; Issue: 3 Linguagem: Inglês

10.1111/j.1348-0421.1971.tb00573.x

0021-5139

Megumi Kono, Koji Ohara, Masatoshi Nagawa, Susumu Mitsuhashi,

Phenothiazines and Benzothiazines Synthesis and Activities

ABSTRACT Induction of chloramphenicol (CM) resistance in Staphylococcus aureus was investigated using 166 CM derivatives and analogues. It was found that 18 compounds of the samples used were able to induce resistance to CM in Staphylococcus aureus S1477 harboring an inducible CM‐resistance determinant. Most of the samples which had a nitrophenyl moiety and a D‐ or DL‐threo isomer in its steric configuration were found to have inducer activity for CM resistance. Competent inducers are D‐isomer CM derivatives which have another substituent in place of the hydroxyl group at carbon atom 3 in the propanediol of the drug.