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Binary Encoding of Compound Libraries

1994; Wiley; Volume: 33; Issue: 15-16 Linguagem: Inglês

10.1002/anie.199415731

1521-3773

Peter Eckes,

Analytical Chemistry and Chromatography

The rapid identification of functional molecules that participate in specific supramolecular interactions is a major problem in the screening of compound libraries. The binary encoding developed by Still et al. allows the structure assignment of “active” compounds according to a simple encoding scheme, and is independent of the synthetic chemistry employed. The viability of this concept has already been demonstrated, but the advantages will first be fully realized with libraries of small organic molecules.