Portal de Periódicos da CAPES

Hormone-related tumors in transsexuals receiving treatment with cross-sex hormones

2008; Oxford University Press; Volume: 159; Issue: 3 Linguagem: Inglês

10.1530/eje-08-0289

1479-683X

Andreas Mueller, Louis Gooren,

Ovarian cancer diagnosis and treatment

To assess the risk of development of hormone-related tumors in transsexuals receiving treatment with cross-sex hormones. Design Description of cases of transsexuals who have developed a hormone-related malignancy observed in their own clinic or reported in the literature. Recommendations for early diagnosis and prevention are presented.Review of the literature in PubMed.In male-to-female transsexuals receiving estrogen administration, lactotroph adenomas, breast cancer, and prostate cancer have been reported. In female-to-male transsexuals receiving treatment with testosterone, a single case of breast carcinoma and several cases of ovarian cancer have been reported. So far endometrial cancer has not been encountered though it remains a potential malignant development.There are so far only a few cases of hormone-related cancer in transsexuals. There may be an underreporting. The probability of a hormone-related tumor increases with the duration of exposure to cross-sex hormones and the aging of the population of transsexuals.