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The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

2015; Elsevier BV; Volume: 25; Issue: 20 Linguagem: Inglês

10.1016/j.cub.2015.08.051

1879-0445

Andrea Musacchio,

14-3-3 protein interactions

The spindle assembly checkpoint is a safeguard mechanism that coordinates cell-cycle progression during mitosis with the state of chromosome attachment to the mitotic spindle. The checkpoint prevents mitotic cells from exiting mitosis in the presence of unattached or improperly attached chromosomes, thus avoiding whole-chromosome gains or losses and their detrimental effects on cell physiology. Here, I review a considerable body of recent progress in the elucidation of the molecular mechanisms underlying checkpoint signaling, and identify a number of unresolved questions.