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Haemolysis in haemodialysis patients: evidence for impaired defence mechanisms against oxidative stress

2000; Oxford University Press; Volume: 15; Issue: 6 Linguagem: Inglês

10.1093/ndt/15.6.883

1460-2385

Talia Weinstein, Avry Chagnac, Asher Korzets, Mona Boaz, Yaacov Ori, Michal Herman, T. Malachi, Uzi Gafter,

Iron Metabolism and Disorders

Background. Uraemic patients have a decreased ability to withstand oxidative stress. It is postulated that their antioxidant capacity is reduced, yet the mechanism remains unclear. Recently 33 haemodialysis (HD) patients were exposed to chloramine contamination in the water supply. This led to haemolysis in 24 patients, while nine were unaffected. In the former group haemoglobin decreased from 11.7±1.1 to 8.5± 1.4 g/dl (P<0.0001) and returned to 11.4±0.9 g/dl (P<0.0001) following recovery. During haemolysis, haptoglobin was 38.4±10.6 vs 138.1±8.3 ng/dl (P<0.0001) following recovery.