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Act1, an NF-κB-activating protein

2000; National Academy of Sciences; Volume: 97; Issue: 19 Linguagem: Inglês

10.1073/pnas.160265197

1091-6490

Xiaoxia Li, Mairead Commane, Huiqin Nie, Xianxin Hua, Moitreyee Chatterjee‐Kishore, David N. Wald, Michael Haag, George R. Stark,

interferon and immune responses

Use of an NF-kappaB-dependent selectable marker facilitated the isolation of a cell line containing a cDNA encoding Act1, an NF-kappaB activator. Act1 associates with and activates IkappaB kinase (IKK), leading to the liberation of NF-kappaB from its complex with IkappaB. Many signaling pathways that liberate NF-kappaB also activate activating transcription factor (ATF) and activator protein 1 (AP-1) through Jun kinase (JNK). Act1 also activates JNK, suggesting that it might be part of a multifunctional complex involved in the activation of both NF-kappaB and JNK. Act1 fails to activate NF-kappaB in an IL-1-unresponsive mutant cell line in which all known signaling components are present, suggesting that it interacts with an unknown component in IL-1 signaling.