Produção Nacional
Revisado por pares
CYP3A5 Genotype, but Not CYP3A4*1b, CYP3A4*22, or Hematocrit, Predicts Tacrolimus Dose Requirements in Brazilian Renal Transplant Patients
2013; Wiley; Volume: 94; Issue: 2 Linguagem: Inglês
10.1038/clpt.2013.68
ISSN1532-6535
AutoresAlberto Santoro, Cláudio J. Struchiner, Carmen Felipe, Hélio Tedesco‐Silva, José Osmar Medina Pestana, Guilherme Suarez‐Kurtz,
Tópico(s)Epilepsy research and treatment
ResumoClinical Pharmacology & TherapeuticsVolume 94, Issue 2 p. 201-202 Letters to the Editor CYP3A5 Genotype, but Not CYP3A4*1b, CYP3A4*22, or Hematocrit, Predicts Tacrolimus Dose Requirements in Brazilian Renal Transplant Patients A B Santoro, A B Santoro Programa de Farmacologia, Instituto Nacional de Câncer, Rio de Janeiro, BrazilSearch for more papers by this authorC J Struchiner, C J Struchiner Programa de Computação Científica, Fundação Oswaldo Cruz, Rio de Janeiro, BrazilSearch for more papers by this authorC R Felipe, C R Felipe Hospital do Rim e Hipertensão, UNIFESP, São Paulo, BrazilSearch for more papers by this authorH Tedesco-Silva, H Tedesco-Silva Hospital do Rim e Hipertensão, UNIFESP, São Paulo, BrazilSearch for more papers by this authorJ O Medina-Pestana, J O Medina-Pestana Hospital do Rim e Hipertensão, UNIFESP, São Paulo, BrazilSearch for more papers by this authorG Suarez-Kurtz, Corresponding Author G Suarez-Kurtz [email protected] Programa de Farmacologia, Instituto Nacional de Câncer, Rio de Janeiro, BrazilSearch for more papers by this author A B Santoro, A B Santoro Programa de Farmacologia, Instituto Nacional de Câncer, Rio de Janeiro, BrazilSearch for more papers by this authorC J Struchiner, C J Struchiner Programa de Computação Científica, Fundação Oswaldo Cruz, Rio de Janeiro, BrazilSearch for more papers by this authorC R Felipe, C R Felipe Hospital do Rim e Hipertensão, UNIFESP, São Paulo, BrazilSearch for more papers by this authorH Tedesco-Silva, H Tedesco-Silva Hospital do Rim e Hipertensão, UNIFESP, São Paulo, BrazilSearch for more papers by this authorJ O Medina-Pestana, J O Medina-Pestana Hospital do Rim e Hipertensão, UNIFESP, São Paulo, BrazilSearch for more papers by this authorG Suarez-Kurtz, Corresponding Author G Suarez-Kurtz [email protected] Programa de Farmacologia, Instituto Nacional de Câncer, Rio de Janeiro, BrazilSearch for more papers by this author First published: 02 April 2013 https://doi.org/10.1038/clpt.2013.68Citations: 11Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1de Jonge, H., de Loor, H., Verbeke, K., Vanrenterghem, Y. & Kuypers, D.R. In vivo CYP3A4 activity, CYP3A5 genotype, and hematocrit predict tacrolimus dose requirements and clearance in renal transplant patients. Clin. Pharmacol. Ther. 92, 366–375 (2012). 10.1038/clpt.2012.109 CASPubMedWeb of Science®Google Scholar 2Santoro, A. et al. Pharmacogenetics of calcineurin inhibitors in Brazilian renal transplant patients. Pharmacogenomics 12, 1293–1303 (2011). 10.2217/pgs.11.70 CASPubMedWeb of Science®Google Scholar 3Hesselink, D.A. et al. Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR–1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus. Clin. Pharmacol. Ther. 74, 245–254 (2003). 10.1016/S0009-9236(03)00168-1 CASPubMedWeb of Science®Google Scholar 4Tavira, B. et al; REDINREN Pharmacogenetics group. Pharmacogenetics of tacrolimus after renal transplantation: analysis of polymorphisms in genes encoding 16 drug metabolizing enzymes. Clin. Chem. Lab. Med. 49, 825–833 (2011). 10.1515/CCLM.2011.143 CASPubMedWeb of Science®Google Scholar 5Elens, L. et al. A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients. Clin. Chem. 57, 1574–1583 (2011). 10.1373/clinchem.2011.165613 CASPubMedWeb of Science®Google Scholar Citing Literature Volume94, Issue2Genomic MedicineAugust 2013Pages 201-202 ReferencesRelatedInformation
Referência(s)