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Relationship between platelet activating factor acetylhydrolase activity and apolipoprotein B levels in patients with peanut allergy

2014; BioMed Central; Volume: 10; Issue: 1 Linguagem: Inglês

10.1186/1710-1492-10-20

1710-1492

Boris Perelman, Areej Adil, Peter Vadas,

Drug-Induced Adverse Reactions

Platelet-activating factor (PAF) is a highly potent phospholipid mediator responsible for the life-threatening manifestations of anaphylaxis. PAF acetylhydrolase (PAF-AH) inactivates PAF and protects against severe anaphylaxis whereas deficiency of PAF-AH predisposes to severe or fatal anaphylaxis. Determinants of PAF-AH activity have not been studied in patients with peanut allergy. To determine whether plasma PAF-AH activity in patients with peanut allergy is related to formation of circulating complexes with apolipoprotein B (apoB) the main surface protein on low density lipoprotein particles. Plasma PAF-AH activity and apoB concentrations were measured in 63 peanut allergic patients (35 boys, 28 girls, ages 2 – 19 years). ApoB concentration was measured immunoturbidimetrically using goat anti-human apoB. The correlation between PAF-AH activity and apoB concentration was determined. A positive correlation was found between PAF-AH activity and apoB concentration (r2 = 0.59, P < 0.0001). In peanut allergic patients, PAF-AH activity strongly correlates with apoB concentration, suggesting the presence of circulating PAF-AH- lipoprotein complexes.