Produção Nacional
Revisado por pares
Predictors of peritoneal carcinomatosis in patients with gastric cancer treated at a single institution in Brazil
2009; Wiley; Volume: 100; Issue: 6 Linguagem: Inglês
10.1002/jso.21349
ISSN1096-9098
AutoresMarcello Ferretti Fanelli, Tadeu Ferreira Paiva, Milton Barros, Carlos Frederico Lopes Benevides, Andréa Paiva Gadêlha Guimarães, Daniel Luiz Gimenes, Edilson D. Pinheiro, José Augusto Rinck, Ulisses Ribaldo Nicolau, Solange Moraes Sanches, Celso Abdon Lopes de Mello, Aldo Lourenço Abbade Dettino, Marcelo Rocha S Cruz, Leila Maria Magalhães Pessoa de Melo, Maria Nirvana Formiga, Vladmir Cláudio Cordeiro de Lima, Ludmilla Thomé Domingos Chinen,
Tópico(s)Ovarian cancer diagnosis and treatment
ResumoPeritoneal carcinomatosis is a common pattern of recurrence in gastric cancer and is associated with a poor prognosis. Determining predictive factors for peritoneal recurrence can help the selection of patients suitable for more aggressive treatment strategies.A retrospective chart review of 162 patients diagnosed with gastric cancer with no peritoneal carcinomatosis and treated at a single institution in Brazil from January 1994 to December 2004 was carried out. Univariate and multivariate analyses were performed to identify patient and tumor-related characteristics associated with the development of peritoneal metastasis.Twenty-three (14.2%) patients developed peritoneal carcinomatosis. Three independent factors associated with the development of peritoneal metastasis were identified by multivariate analysis: signet-ring cell histology (odds ratio [OR] = 4.9; P = 0.018), the presence of vascular invasion (OR = 4.8; P = 0.022), and the presence of visceral metastasis at diagnosis (OR = 5.1; P = 0.011). Tumor stages T3 or T4 showed a trend towards significance (P = 0.062).Patients with gastric cancer presenting with signet-ring histology, vascular invasion, or visceral metastasis appear to be at higher risk for the development of peritoneal carcinomatosis.
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