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Methodology of a nationwide cross-sectional survey of prevalence and epidemiological patterns of hepatitis A, B and C infection in Brazil

2010; Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz; Volume: 26; Issue: 9 Linguagem: Inglês

10.1590/s0102-311x2010000900003

1678-4464

Ricardo Arraes de Alencar Ximenes, Leila Maria Beltrão Pereira, Celina Maria Turchi Martelli, Edgar Merchán-Hamann, Aírton Tetelbom Stein, Gerusa Maria Figueiredo, Cynthia Braga, Ulísses Ramos Montarroyos, Leila Melo Brasil, Marília Dalva Turchi, José Carlos Ferraz da Fonseca, Maria Luíza Carvalho de Lima, Luis Cláudio Arraes de Alencar, Marcelo A. Costa, Gabriela Perdomo Coral, Regina Célia Moreira, Maria Regina Alves Cardoso,

Hepatitis Viruses Studies and Epidemiology

A population-based survey to provide information on the prevalence of hepatitis viral infection and the pattern of risk factors was carried out in the urban population of all Brazilian state capitals and the Federal District, between 2005 and 2009. This paper describes the design and methodology of the study which involved a population aged 5 to 19 for hepatitis A and 10 to 69 for hepatitis B and C. Interviews and blood samples were obtained through household visits. The sample was selected using stratified multi-stage cluster sampling and was drawn with equal probability from each domain of study (region and age-group). Nationwide, 19,280 households and ~31,000 residents were selected. The study is large enough to detect prevalence of viral infection around 0.1% and risk factor assessments within each region. The methodology seems to be a viable way of differentiating between distinct epidemiological patterns of hepatitis A, B and C. These data will be of value for the evaluation of vaccination policies and for the design of control program strategies.