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The Vertebrate Genome Annotation browser 10 years on

2013; Oxford University Press; Volume: 42; Issue: D1 Linguagem: Inglês

10.1093/nar/gkt1241

1362-4962

Jennifer Harrow, Charles A. Steward, Adam Frankish, James Gilbert, José M. González, Jane Loveland, Jonathan M. Mudge, Dan Sheppard, Mark Thomas, Stephen J. Trevanion, Laurens Wilming,

Genomics and Phylogenetic Studies

Abstract The Vertebrate Genome Annotation (VEGA) database (http://vega.sanger.ac.uk), initially designed as a community resource for browsing manual annotation of the human genome project, now contains five reference genomes (human, mouse, zebrafish, pig and rat). Its introduction pages have been redesigned to enable the user to easily navigate between whole genomes and smaller multi-species haplotypic regions of interest such as the major histocompatibility complex. The VEGA browser is unique in that annotation is updated via the Human And Vertebrate Analysis aNd Annotation (HAVANA) update track every 2 weeks, allowing single gene updates to be made publicly available to the research community quickly. The user can now access different haplotypic subregions more easily, such as those from the non-obese diabetic mouse, and display them in a more intuitive way using the comparative tools. We also highlight how the user can browse manually annotated updated patches from the Genome Reference Consortium (GRC).