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Bacteriological Analysis and Antibiotic Sensitivity Pattern of Blood Culture Isolates in Kanti Children Hospital

2010; Nepal Paediatric Society; Volume: 30; Issue: 2 Linguagem: Inglês

10.3126/jnps.v30i2.2482

1990-7982

Shubana Karki, Ganesh Kumar, Rekha Manandhar,

Neonatal and Maternal Infections

Introduction: As antibiotic sensitivity pattern to common pathogen has been changing day by day, so ithas been necessary to study about bacteriological analysis and antibiotic sensitivity pattern. Therefore,the purpose of this study was to analyze on data on bacteremia in children, the pathogen involved andsensitivity pattern. Objectives: The aim of this study was to determine the bacteriological profile andantibiotic sensitivity pattern of blood culture isolates from Kanti Children Hospital. Method: All bloodculture reports (n=9856) during one year period (April 2007 to March 2008) included in the study wereanalyzed and the sensitivity pattern were recorded. In this retrospective study, we reviewed records ofpatients from Kanti Children Hospital from April 2007 to March 2008. Results: The positivity of bloodculture was 4.2% (414/9856). Out of them, 269 (65%) were positive for Staphylococcus aures, 121(29.3%)E coli, 13(3.1%) Klebsiella pneumonia, 6(1.4%) Streptococcus pneumonia and 5(1.2%) Streptococcusviridence. Staphylococcus aureus was found most sensitive to Chloramphenicol (88.8%) followed byAmikacin (87.5%), Ofloxacin (76.5%), Ciprofloxacin (72%) and least sensitive to Ampicillin, Cloxacillin andPenicillin. E.coli was found most sensitive to Amikacin (74.7%) followed by Ofloxacin (69.9%), Ciprofloxacin(56.4%) and least sensitive to Cephalexin, Gentamycin and Ampicillin. Klebsiella pneumoniae wasfound most sensitive to Amikacin (91.7%) followed by Ofloxacin (87.5%), Chloramphenical (81.8%) andleast sensitive to Cotrimoxazole and Gentamycin. It is 100% resistance to Ampicillin and Erythromycin.Streptococcus pneumoniae was most sensitive to Penicillin, Chloramphenical (100%) followed byAmpicillin and Erythromycin (83.3%) and least sensitive to Cotrimoxazole. Streptococcus viridence wasmost sensitive to Chloramphenical (100%) followed by Erythromycin (80%), Penicillin (75%) and leastsensitive to Cotrimoxazole. Conclusion: This highlights the variable nature of antibiotic susceptibilitypatterns both in time and location around different geographical locations and within the same country aswell. Therefore, it is advisable to continuously evaluate the sensitivity-resistance pattern of isolates so asto make a rational use of antibiotics.Key words: Antibiotic sensitivity; bacteremia; blood culture; neonatal sepsis.DOI: 10.3126/jnps.v30i2.2482J. Nepal Paediatr. Soc. May-August, 2010 Vol 30(2) 94-97