Growth Hormone (GH) Provocative Retesting of 108 Young Adults with Childhood-Onset GH Deficiency and the Diagnostic Value of Insulin-Like Growth Factor I (IGF-I) and IGF-Binding Protein-3 1
1997; Oxford University Press; Volume: 82; Issue: 4 Linguagem: Inglês
10.1210/jcem.82.4.3892
ISSN1945-7197
AutoresAnders Juul, K W Kastrup, Søren A. Pedersen, Niels E. Skakkebæk,
Tópico(s)Genetic Syndromes and Imprinting
ResumoSerum levels of total insulin-like growth factor I (IGF-I) and IGF-binding protein-3 (IGFBP-3) reflect the endogenous GH secretion in healthy children and exhibit little diurnal variation, which makes them good diagnostic markers for screening of GH deficiency (GHD) in short children, although some controversy still exists. In adults, the diagnostic value of IGF-I and IGFBP-3 suspected of GHD has been reported in only a few studies.
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