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Humoral and Cellular Response in Humans After Immunization with Influenza Vaccine

1973; American Society for Microbiology; Volume: 7; Issue: 4 Linguagem: Inglês

10.1128/iai.7.4.594-596.1973

1098-5522

Frederick L. Ruben, George Gee Jackson, Samuel P. Gotoff,

Immune Cell Function and Interaction

The peripheral blood lymphocyte response and hemagglutination inhibition antibody titers were measured in nine adults before and after immunization with a killed split influenza virus vaccine. Cord blood lymphocytes were tested with the influenza antigen to exclude a nonspecific mitogenic effect. All of the subjects demonstrated preexisting antibody titers and antigen recognition by lymphocytes prior to immunization. The in vitro lymphocyte response after vaccination parallels the humoral antibody response to influenza antigen.