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Autoimmune progesterone dermatitis manifested as erythema annulare centrifugum: Confirmation of progesterone sensitivity by in vitro interferon-? release

2002; Elsevier BV; Volume: 47; Issue: 2 Linguagem: Inglês

10.1067/mjd.2002.121345

1097-6787

Sima Halevy, Arnon D. Cohen, Eitan Lunenfeld, Nili Grossman,

Autoimmune Bullous Skin Diseases

Autoimmune progesterone dermatitis was manifested as deep-type erythema annulare centrifugum. Sensitivity to progesterone was studied in vivo by means of intradermal and patch tests, which revealed immediate-type and delayed-type hypersensitivity, respectively. Sensitivity to progesterone was further confirmed in vitro by results of an interferon-gamma release test, which imply a possible role for T(H)1-type cytokines in autoimmune progesterone dermatitis.