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MILVA: An interactive tool for the exploration of multidimensional microarray data

2005; Oxford University Press; Volume: 21; Issue: 22 Linguagem: Inglês

10.1093/bioinformatics/bti676

1367-4811

Davide D’Alimonte, David Lowe, Ian T. Nabney, Vassilis Mersinias, Colin P. Smith,

Gene Regulatory Network Analysis

Abstract Motivation: Clustering techniques such as k-means and hierarchical clustering are commonly used to analyze DNA microarray derived gene expression data. However, the interactions between processes underlying the cell activity suggest that the complexity of the microarray data structure may not be fully represented with discrete clustering methods. Results: A newly developed software tool called MILVA (microarray latent visualization and analysis) is presented here to investigate microarray data without separating gene expression profiles into discrete classes. The underpinning of the MILVA software is the two-dimensional topographic representation of multidimensional microarray data. On this basis, the interactive MILVA functions allow a continuous exploration of microarray data driven by the direct supervision of the biologist in detecting activity patterns of co-regulated genes. Availability: The MILVA software is freely available. The software and the related documentation can be downloaded from . User ‘surrey’ as username and ‘3245’ as password to login. The software is currently available for Windows platform only. Contact: d.lowe@aston.ac.uk