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Aptamer‐Based Switchable Nanovalves for Stimuli‐Responsive Drug Delivery

2011; Wiley; Volume: 17; Issue: 36 Linguagem: Inglês

10.1002/chem.201101403

1521-3765

Veli Cengiz Özalp, Thomas Schäfer,

DNA and Nucleic Acid Chemistry

Molecular gates: A new approach in developing controlled drug-delivery systems using aptamers as nanovalves is presented. For the proof of principle, mesoporous silica nanoparticles were modified with a hairpin form of ATP-binding DNA, which allows encapsulation and release of guest molecules controlled by ATP. This reversible aptamer-based nanogate function could provide novel trigger systems for any desired biological stimulus in drug-delivery applications.